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AHEAD Trial — AI-Generated Medical Exam Questions Match Human-Written Ones on Most Measures, With a Flagged Equity Gap

Canada · Vancouver · See the Canada profile · See the Vancouver profile

Evidence: Randomised controlled trial Top 56% 47/100 · Ask Evidence Copilot about this practice

A blinded RCT of 258 first-year UBC medical students found AI-generated exam questions were made 5.6x faster than student-written ones, with similar scores and acceptability, though human items discriminated slightly better and a gender gap emerged only on the AI exam.

258 students
Students randomized (Dec 2024)
112 items
Exam items (Dec 2024)
4.2 minutes
Time per item: AI-generated
19.6 minutes
Time per item: human-written
5.6 x faster
Item-writing efficiency gain (AI vs human)
73.4 %
Exam score, human-generated exam
71.0 %
Exam score, AI-generated exam
AHEAD Trial — AI-Generated Medical Exam Questions Match Human-Written Ones on Most Measures, With a Flagged Equity Gap

Details

Maturity
Pilot
Promoter
University of British Columbia Faculty of Medicine
Period
December 2024 (published June 2026)
Keywords
higher education, medical education, assessment design, academic integrity

Context

Writing a single high-quality multiple-choice exam question for medical education can take instructors or item-writers well over an hour and cost an estimated US$200 to over US$2,000 per usable item, making large question banks expensive to build and maintain.

Objectives

Test whether AI-generated exam questions can match human-written ones on exam performance, item quality and student acceptability, while quantifying the time savings.

Activities

The University of British Columbia Faculty of Medicine ran the AHEAD Trial on 8-9 December 2024, randomizing 258 first-year MD students 1:1 to a blinded 112-item mock exam built either by senior medical students (human-generated) or by a ChatGPT-4-plus-Google-Gemini validation pipeline (AI-generated), with all authorship indicators stripped before delivery.

Results

AI-generated items took 4.2 minutes each to produce versus 19.6 minutes for human-written items, a 5.6-fold efficiency gain (p<0.0001). Overall exam scores were statistically similar (73.4% human-generated vs 71.0% AI-generated, p=0.083). Human-written items had modestly but significantly higher item-discrimination scores (small effect), and student-rated acceptability favoured the human exam on four of nine measures with small effect sizes (Cohen's d <=0.32). Neither exam meaningfully changed students' self-rated exam readiness. An exploratory subgroup analysis found male students outperforming female students on the AI-generated exam (rrb=0.26) but not on the human-generated exam (rrb=0.07).

Conclusions

AI-generated items matched human-written ones on most measures at a fraction of the production time, but the trial was single-center, first-year-only, used senior students rather than faculty as question-writers, was registered retrospectively, and flags the gender-gap signal as requiring demographic monitoring rather than a confirmed effect.

Implementation

Indicative cost
Low (< €50k) — AI-generated items required far less staff time to produce (4.2 vs 19.6 minutes each) than human-written items, implying lower marginal item-writing cost; no absolute dollar figure was reported for this trial.
Time to results
Short (< 1 year) — A single 2-day mock-exam event (8-9 December 2024), with the AI validation pipeline built beforehand.
Staffing & skills
University of British Columbia Faculty of Medicine research team, Senior medical students as human item-writers, ChatGPT-4 + Google Gemini validation pipeline for AI-generated items

Conditions for success

  • Blinded delivery with authorship indicators stripped from all items
  • Pre-specified, CONSORT-compliant analysis plan with IRB approval
  • Validation pipeline combining two AI models for item generation

Common failure modes

  • Single-center, first-year-students-only design limits generalisability
  • Question-writers were senior students rather than faculty
  • Trial registered retrospectively
  • Exploratory subgroup gender-gap finding is likely underpowered

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